Photo Joseph Brunet portrait

About me

Hi, I'm Joseph Brunet, a Post-Doctoral Research Fellow in biomedical at University College London, based at European Synchrotron Radiation Facility (ESRF).

I am part of an international team headed by Professor Peter Lee, which uses a new imaging technique called Hierarchical Phase contrast Computed Tomography (HiP-CT) to image whole human organs. This was enabled by the recent upgrade to the ESRF in Grenoble. We recently made fondamental discoveries in the mechanicsms behind COVID-19 effect on lung vasculature.

Curriculum vitae

I'm a curious mind, always looking for new experiences and problems to solve. This has led me to explore different fields like mechanics, biology or imaging, and combined them to open perspectives on the development of personalised diagnostic tools for patients.

Research

Tension-inflation experiment at the synchrotron

Aortic dissection

Understanding the mechanisms of aortic dissection

Artic dissection
Tension-inflation
Synchrotron X-ray tomography

During my PhD, I worked at identifying and quantifying the mechanisms behind vascular failure and especially aortic dissection in order to develop new diagnostic tools and treatments for clinics. To this end, I performed in situ experiments combining mechanical testing and imaging techniques. I created an in vitro aortic dissection and I observed it with X-ray micro-tomography, using either laboratory or synchrotron X-ray sources. This approach made it possible to observe the 3D evolution of the delamination profile during the propagation of a dissection in the aortic wall. Inverse methods allowed me to quantify the elastic and failure properties of the aorta. Finilly, I used finite element models to model the rupture and investigate the fracture modes of the tissue.

Publications Icon research publication

You can also find my scientific publications on my Google Scholar profile.

2022

  • Brunet J., Walsh, C. L., Wagner, W. L., Bellier, A., Werlein, C., Marussi, S., Jonigk, D. D., Verleden, E. S., Ackermann, M., Lee, D. P., Tafforeau, P. Preparation of large biological samples for high-resolution, hierarchical, multi-modal imaging. Nature Protocols, 2022. Accepted (on BioRxiv).

  • Brunet J., Pierrat, B., Adrien, J., Maire, E., Lane, B. A., Curt, N., Bravin, A., Laroche, N., Badel, P. In situ visualization of aortic dissection propagation in notched rabbit aorta using synchrotron X-ray tomography. Acta Biomaterialia, 2022. In Press.

2021

  • Brunet J., Pierrat B., and Badel P. A parametric study on factors influencing the onset and propagation of aortic dissection using the extended finite element method. IEEE Transactions on Biomedical Engineering, vol. 68, pp. 2918-2929, 2021.

2020

  • Brunet J., Pierrat B., Adrien, J., Maire, E., Curt, N., and Badel P. A Novel Method for In Vitro 3D Imaging of Dissecting Pressurized Arterial Segments Using X-Ray Microtomography. Experimental Mechanics, vol. 61, pp. 147–157, 2020.  

  • Brunet J., Pierrat B., and Badel P. Review of current advances in the mechanical description and quantification of aortic dissection mechanisms. IEEE Reviews in Biomedical Engineering, vol. 14, pp. 240-255, 2020.  

2019

  • Brunet J., Pierrat B., Maire E., Adrien, J., and Badel P. A combined experimental-numerical lamellar-scale approach of tensile rupture in arterial medial tissue using X-ray tomography. Journal of the mechanical behavior of biomedical materials, vol. 95, pp. 116-123, 2019.  

Conferences

2022

  • BioMedEng22 (8 September)
    Oral presentation delivered entitled: In situ quantification of the mechanical behavior of coronary arteries during angioplasty using synchrotron X-ray tomography in intact porcine hearts, London, United Kingdom.

  • 5th International Conference on Tomography of Materials and Structures (ICTMS2022) (July 26)
    Oral presentation delivered entitled: High-resolution imaging of whole human heart using synchrotron x-ray tomography, Grenoble, France.

2021

  • 26th Congress of the European Society of Biomechanics (ESBiomech2020) (July 11)
    Oral presentation delivered entitled: 3D characterization of crack propagation during the onset of a dissection using X-ray microtomography on pressurized aortic segments, Online.

  • 46th Congress of the Société de Biomécanique (October 25)
    Oral presentation delivered entitled: In situ observation of an in vitro aortic dissection in rabbit aortic tissue with synchrotron-based X-ray microtomography, Saint-Etienne, France.

2020

  • 45th Congress of the Société de Biomécanique (October 28)
    Oral presentation delivered entitled: Investigation of notch propagation in an in-vitro dissection model using X-ray microtomography, Online.

2019

  • 44th Congress of the Société de Biomécanique (October 30)

    Chairman of the session ”Macro-scale biofluids” and oral presentation delivered entitled: A numerical design of experiment approach to understand aortic dissection onset and propagation, Poitiers, France.

2018

  • 8th World Congress of Biomechanics (July 10)
    Poster presentation delivered entitled: A combined experimental-numerical meso-scale approach of tensile rupture in arterial medial tissue using X-ray tomography, Dublin, Ireland.

  • 15th International Symposium on Computer Methods in Biomechanics and Biomedical Engineering (March 28)
    Oral presentation delivered entitled: Characterization and modelling of rupture in arterial medial tissue under tension from in situ experiments with X-ray tomography, Lisbon, Portugal.

Teaching

Teaching Assistant, Ecole des Mines de Saint-Etienne

  • Experimental mechanics

  • Finite element method

  • Supervisor of master students - Industrial and research projects